Adult Stem Cell Orthopedics
What is the Science?
For this procedure, Dr. Mavrick harvests your Mesenchymal stem cells (MSCs) from what is known as AD-SVF, or Adipose Derived-Stromal Vascular Fraction. AD-SVF provides a rich source of your own mesenchymal stem cells. These specific tissue fractions are located within the highly vascular adipose bed, which serve to nurture and protect your stem cell population. This combination of stem cells, native tissue matrix and bio-scaffolding act together to repair and regenerate affected tissues. When harvested along with the stem cells, and mixed with your own platelet rich plasma, these tissue products provide the potent combination of cytokines, cell signals, and scaffolding necessary for MSCs to differentiate and repair the target injury.
What makes your adipose the ideal harvest tissue for you?
The stem cell concentration in adipose tissue is in your fat which is at least 1000 times higher than it is in your bone marrow aspirate. Another advantage is that your own AD-SVF contains the full complement of matrix tissue fractions necessary for cartilage, ligament, and tendon and fascia regeneration. Bone marrow contains none of these matrix tissues. Up to 45% of the nucleated cells within adipose tissue are Mesenchymal stem cells. Therefore, your adipose tissue is the most ideal site for harvesting stem cells.
How is the procedure done?
The harvesting procedure is minimally invasive and from start to finish takes about 2.5 hours. First, a small ¼” incision is made in the skin and a patented tissue harvester is inserted and used to extract your adipose derived stem cells. Next we separate and concentrate the AD-SVF that contains your stem cells and tissue matrix. Then, a 4-ounce quantity of blood is drawn and your platelet rich plasma (PRP) is concentrated. The PRP is combined with the Stromal Vascular Fraction (AD-SVF) to activate the Mesenchymal stem cells. The PRP and the AD-SVF concentrates activate the stem cells and immediately injected under ultrasound guidance into your affected area: hip joint, knee joint, lumbar spine, shoulder, etc.